In contrast, reserpine (20 and 40 mg/L) did not evoke overt acute behavioral effects, but markedly reduced activity 7 days later, resembling motor retardation observed in depression and/or Parkinson's disease. Overall, d-amphetamine (5 and 10mg/L) evokes anxiogenic-like effects in zebrafish acutely, but not 7 days later. Here, we have examined the acute and long-term effects of reserpine and d-amphetamine on zebrafish behavior in the novel tank test. ![]() Zebrafish (Danio rerio) are rapidly emerging as a promising model organism for drug screening and translational neuroscience research. However, the effects of these agents on behavior and in relation to monoamine levels remain poorly understood, necessitating further experimental studies to understand their psychotropic action. In contrast, d-amphetamine increases brain monoamines' levels, and evokes hyperactivity and anxiety. Reserpine depletes monoamines, and causes depression and hypoactivity in humans and rodents. ![]() Cigna may not control the content or links of non-Cigna websites.Brain monoamines play a key role in the regulation of behavior. Selecting these links will take you away from to another website, which may be a non-Cigna website. This website is not intended for residents of New Mexico. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. LINA and NYLGICNY are not affiliates of Cigna.Īll insurance policies and group benefit plans contain exclusions and limitations. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT) (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA) or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. That insure or administer group HMO, dental HMO, and other products or services in your state). Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., Cigna HealthCare of Georgia, Inc., Cigna HealthCare of North Carolina, Inc., Cigna HealthCare of South Carolina, Inc., and Cigna HealthCare of Texas, Inc. įind an in-network doctor, dentist, or facility If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.Ĭopyright 1996-2023 Cerner Multum, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. ![]() Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drug information contained herein may be time sensitive. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. ![]() Every effort has been made to ensure that the information provided by Cerner Multum, Inc.
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